Moreo, E., Uranga, S., Picó, A., Gómez, A.B., Nardelli-Haefliger, D., Del Fresno, C., Murillo, I., Puentes, E., Rodríguez, E., Vales-Gómez, M., Pardo, J., Sancho, D., Martín, C., Aguilo, N., Novel intravesical bacterial immunotherapy induces rejection of BCG-unresponsive established bladder tumors, 2022, Journal for ImmunoTherapy of Cancer, vol 10 (7), DOI: 10.1136/jitc-2021-004325.
Pérez, I., Campos-Pardos, E., Díaz, C., Uranga, S., Sayes, F., Vicente, F., Aguiló, N., Brosch, R., Martín, C., Gonzalo-Asensio, J., The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy, 2022, Molecular Therapy – Nucleic Acids, Vol 27, DOI: 10.1016/j.omtn.2022.02.011
Martín, C., Marinova, D., Aguiló, N., Gonzalo-Asensio, J., MTBVAC, a live TB vaccine poised to initiate efficacy trials 100 years after BCG, 2021, Vaccine, Vol 39(50), DOI: 10.1016/j.vaccine.2021.06.049
White A.D., Sibley L., Sarfas C., Morrison A., Gullick J., Clark S., Gleeson F., McIntyre A., Arlehamn C.L., Sette A., Salguero F.J., Rayner E., Rodriguez E., Puentes E., Laddy D., Williams A., Dennis M., Martin C., Sharpe S., MTBVAC vaccination protects rhesus macaques against aerosol challenge with M. tuberculosis and induces immune signatures analogous to those observed in clinical studies, 2021, npj Vaccines, Vol 6(1) DOI: 10.1038/s41541-020-00262-8
Broset E., Pardo-Seco J., Kanno A.I., Aguilo N., Dacosta A.I., Rivero-Calle I., Gonzalo-Asensio J., Locht C., Leite L.C.C., Martin C., Martinón-Torres F., BCG vaccination improves DTaP immune responses in mice and is associated with lower pertussis incidence in ecological epidemiological studies, 2021, EBioMedicine, Vol 65, DOI: 10.1016/j.ebiom.2021.103254
Broset E., Calvet Seral J., Arnal C., Uranga S., Kanno A.I., Leite L.C.C., Martín C., Gonzalo-Asensio J., Engineering a new vaccine platform for heterologous antigen delivery in live-attenuated Mycobacterium tuberculosis, 2021,Computational and Structural Biotechnology Journal, Vol 19, DOI:10.1016/j.csbj.2021.07.035
Tarancón R., Mata E., Uranga S., Gómez A.B., Marinova D., Otal I., Martín C., Aguiló N., Therapeutic efficacy of pulmonary live tuberculosis vaccines against established asthma by subverting local immune environment, 2021, EBioMedicine, Vol 64,DOI: 10.1016/j.ebiom.2020.103186
Dijkman K., Aguilo N., Boot C., Hofman S.O., Sombroek C.C., Vervenne R.A.W., Kocken C.H.M., Marinova D., Thole J., Rodríguez E., Vierboom M.P.M., Haanstra K.G., Puentes E., Martin C., Verreck F.A.W., Pulmonary MTBVAC vaccination induces immune signatures previously correlated with prevention of tuberculosis infection, 2021, Cell Reports Medicine, DOI: 10.1016/j.xcrm.2020.100187
Vierboom M.P.M., Dijkman K., Sombroek C.C., Hofman S.O., Boot C., Vervenne R.A.W., Haanstra K.G., van der Sande M., van Emst L., Domínguez-Andrés J., Moorlag S.J.C.F.M., Kocken C.H.M., Thole J., Rodríguez E., Puentes E., Martens J.H.A., van Crevel R., Netea M.G., Aguilo N., Martin C., Verreck F.A.W., Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination, 2021, Cell Reports Medicine, Vol 2 (1), DOI: 10.1016/j.xcrm.2020.100185
Mata E., Tarancon R., Guerrero C., Moreo E., Moreau F., Uranga S., Gomez A.B., Marinova D., Domenech M., Gonzalez-Camacho F., Monzon M., Badiola J., Dominguez-Andres J., Yuste J., Anel A., Peixoto A., Martin C., Aguilo N., Pulmonary BCG induces lung-resident macrophage activation and confers long-term protection against tuberculosis, 2021, Science Immunology, Vol 6 (66) DOI: 10.1126/sciimmunol.abc2934
Mata E., Farrell D., Ma R., Uranga S., Gomez A.B., Monzon M., Badiola J., Anel A., Gonzalo-Asensio J., Martin C., Gordon S.V., Aguilo N., Independent genomic polymorphisms in the PknH serine threonine kinase locus during evolution of the Mycobacterium tuberculosis Complex affect virulence and host preference, 2020, PLoS Pathogens, Vol 16 (12) DOI: 10.1371/journal.ppat.1009061
Aguilo N., Uranga S., Mata E., Tarancon R., Gómez A.B., Marinova D., Otal I., Monzón M., Badiola J., Montenegro D., Puentes E., Rodríguez E., Vervenne R.A.W., Sombroek C.C., Verreck F.A.W., Martín C., Respiratory Immunization With a Whole Cell Inactivated Vaccine Induces Functional Mucosal Immunoglobulins Against Tuberculosis in Mice and Non-human Primates, 2020, Frontiers in Microbiology, Vol 11, DOI: 10.3389/fmicb.2020.01339
Pérez I., Uranga S., Sayes F., Frigui W., Samper S., Arbués A., Aguiló N., Brosch R., Martín C., Gonzalo-Asensio J., Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential, 2020,EBioMedicine, Vol 55, DOI 10.1016/j.ebiom.2020.102761
Martin C., Aguilo N., Marinova D., Gonzalo-Asensio J., Update on TB vaccine pipeline, 2020, Applied Sciences (Switzerland), Vol 10 (7), 10.3390/app10072632
Tarancón R., Domínguez-Andrés J., Uranga S., Ferreira A.V., Groh L.A., Domenech M., González-Camacho F., Riksen N.P., Aguilo N., Yuste J., Martín C., Netea M.G., New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia, 2020, PLoS Pathogens, Vol 16 (4), DOI: 10.1371/journal.ppat.1008404
Tovar M., Arregui S., Marinova D., Martín C., Sanz J., Moreno Y., Bridging the gap between efficacy trials and model-based impact evaluation for new tuberculosis vaccines, 2019, Nature Communications, Vol 10 (1) DOI: 10.1038/s41467-019-13387-9
Tarancón R., Uranga S., Martín C., Aguiló N., Mycobacterium tuberculosis infection prevents asthma and abrogates eosinophilopoiesis in an experimental model, 2019, Allergy: European Journal of Allergy and Clinical Immunology, Vol 74 (12), DOI: 10.1111/all.13923
Tarancón R., Uranga S., Martín C., Aguiló N., Mycobacterium tuberculosis infection prevents asthma and abrogates eosinophilopoiesis in an experimental model, 2019, Allergy: European Journal of Allergy and Clinical Immunology, Vol 74(12) DOI: 10.1111/all.13923
Tameris M., Mearns H., Penn-Nicholson A., Gregg Y., Bilek N., Mabwe S., Geldenhuys H., Shenje J., Luabeya A.K.K., Murillo I., Doce J., Aguilo N., Marinova D., Puentes E., Rodríguez E., Gonzalo-Asensio J., Fritzell B., Thole J., Martin C., Scriba T.J., Hatherill M., Africa H., Arendsen D., Botes N., Cloete Y., De Kock M., Erasmus M., Jack L., Kafaar F., Kalepu X., Khomba N.G., Kruger S., Leopeng T., Makhethe L., Mouton A., Mulenga H., Musvosvi M., Noble J., Opperman F., Reid T., Rossouw S., Schreuder C., Smit E., Steyn M., Tyambethu P., Van Rooyen E., Veldsman A., MTBVAC Clinical Trial Team, Live-attenuated Mycobacterium tuberculosis vaccine MTBVAC versus BCG in adults and neonates: a randomised controlled, double-blind dose-escalation trial,2019, The Lancet Respiratory Medicine, Vol 7(9)DOI: 10.1016/S2213-2600(19)30251-6
Díaz C., Pérez Del Palacio J., Valero-Guillén P.L., Mena García P., Pérez I., Vicente F., Martín C., Genilloud O., Sánchez Pozo A., Gonzalo-Asensio J., Comparative Metabolomics between Mycobacterium tuberculosis and the MTBVAC Vaccine Candidate, 2019, ACS Infectious Diseases, Vol 5(8), 10.1021/acsinfecdis.9b00008
Broset E., Saubi N., Guitart N., Aguilo N., Uranga S., Kilpeläinen A., Eto Y., Hanke T., Gonzalo-Asensio J., Martín C., Joseph-Munné J., MTBVAC-Based TB-HIV Vaccine Is Safe, Elicits HIV-T Cell Responses, and Protects against Mycobacterium tuberculosis in Mice,2019, Molecular Therapy – Methods and Clinical Development, Vol 13, DOI: 10.1016/j.omtm.2019.01.014
Gonzalo-Asensio J., Aguilo N., Marinova D., Martin C., Breaking transmission with vaccines: The case of tuberculosis, 2019, Microbial Transmission, DOI: 10.1128/9781555819743.ch14
Martin C., Aguilo N., Gonzalo-Asensio J., Vaccination against tuberculosis [Vacunación frente a tuberculosis]2018, Enfermedades Infecciosas y Microbiologia Clinica, Vol 36 (10) DOI: 10.1016/j.eimc.2018.02.006
Alvarez-Arguedas S., Uranga S., Martín M., Elizalde J., Gomez A.B., Julián E., Nardelli-Haefliger D., Martín C., Aguilo N., Therapeutic efficacy of the live-attenuated Mycobacterium tuberculosis vaccine, MTBVAC, in a preclinical model of bladder cancer, 2018, Translational Research, Vol 197, 10.1016/j.trsl.2018.03.004
Arregui S., Iglesias M.J., Samper S., Marinova D., Martin C., Sanz J., Moreno Y., Data-driven model for the assessment of mycobacterium tuberculosis transmission in evolving demographic structures,2018, Proceedings of the National Academy of Sciences of the United States of America, Vol 115 (14) DOI: 10.1073/pnas.1720606115
Gonzalo-Asensio J., Pérez I., Aguiló N., Uranga S., Picó A., Lampreave C., Cebollada A., Otal I., Samper S., Martín C., New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages, 2018, PLoS Genetics, Vol 14 (4)DOI: 10.1371/journal.pgen.1007282
Gonzalo-Asensio J., Marinova D., Martin C., Aguilo N., MTBVAC: Attenuating the human pathogen of tuberculosis (TB) toward a promising vaccine against the TB epidemic, 2017, Frontiers in Immunology, Vol 8 (DEC), DOI: 10.3389/fimmu.2017.01803
Clark S., Lanni F., Marinova D., Rayner E., Martin C., Williams A., Revaccination of Guinea pigs with the live attenuated Mycobacterium tuberculosis vaccine MTBVAC improves BCG’s protection against tuberculosis, 2017, Journal of Infectious Diseases, Vol 216 (5)DOI: 10.1093/infdis/jix030
Aguilo N., Gonzalo-Asensio J., Alvarez-Arguedas S., Marinova D., Gomez A.B., Uranga S., Spallek R., Singh M., Audran R., Spertini F., Martin C., Revaccination of Guinea pigs with the live attenuated Mycobacterium tuberculosis vaccine MTBVAC improves BCG’s protection against tuberculosis, 2017, Nature Communications, Vol 8, DOI: 10.1038/ncomms16085
Gonzalo-Asensio J., Aguilo N., Marinova D., Martin C., Breaking transmission with vaccines: The case of tuberculosis, 2017, Microbiology Spectrum Vol 5(4)DOI: 10.1128/microbiolspec.MTBP-0001-2016
Marinova D., Gonzalo-Asensio J., Aguilo N., Martin C., MTBVAC from discovery to clinical trials in tuberculosis-endemic countries, 2017, Expert Review of Vaccines, Vol. 16(6) DOI 10.1080/14760584.2017.1324303
Uranga S., Marinova D., Martin C., Aguilo N., Protective efficacy and pulmonary immune response following subcutaneous and intranasal BCG administration in mice, 2016, Journal of Visualized Experiments, 2016, DOI: 10.3791/54440
Uranga S., Marinova D., Martin C., Pardo J., Aguilo N., Granzyme a is expressed in mouse lungs during mycobacterium tuberculosis infection but does not contribute to protection in vivo, 2016, PLoS ONE, Vol. 11(4) DOI: 10.1371/journal.pone.0153028
Scriba T.J., Kaufmann S.H.E., Lambert P.H., Sanicas M., Martin C., Neyrolles O., Vaccination against tuberculosis with whole-cell mycobacterial vaccines, 2016, Journal of Infectious Diseases, Vol 214 (5) DOI: 10.1093/infdis/jiw228
Arregui S., Sanz J., Marinova D., Martín C., Moreno Y., On the impact of masking and blocking hypotheses for measuring the efficacy of new tuberculosis vaccines, 2016, PeerJ, Vol. 2016 (2), DOI: 10.7717/peerj.1513
Aguilo N., Uranga S., Marinova D., Monzon M., Badiola J., Martin C., MTBVAC vaccine is safe, immunogenic and confers protective efficacy against Mycobacterium tuberculosis in newborn mice, 2016, Tuberculosis, Vol. 96, 10.1016/j.tube.2015.10.010
Aguilo N., Alvarez-Arguedas S., Uranga S., Marinova D., Monzón M., Badiola J., Martin C., Pulmonary but not subcutaneous delivery of BCG vaccine confers protection to tuberculosis-susceptible mice by an interleukin 17-dependent mechanism, 2015, Journal of Infectious Diseases, Vol 212 (11), DOI: 10.1093/infdis/jiv503
Spertini F., Audran R., Chakour R., Karoui O., Steiner-Monard V., Thierry A.-C., Mayor C.E., Rettby N., Jaton K., Vallotton L., Lazor-Blanchet C., Doce J., Puentes E., Marinova D., Aguilo N., Martin C., Safety of human immunisation with a live-attenuated Mycobacterium tuberculosis vaccine: A randomised, double-blind, controlled phase I trial, 2015, The Lancet Respiratory Medicine, Vol 3(12), 10.1016/S2213-2600(15)00435-X
Broset E., Martín C., Gonzalo-Asensio J., Evolutionary landscape of the mycobacterium tuberculosis complex from the viewpoint of phoPR: Implications for virulence regulation and application to vaccine development, 2015, mBio, Vol. 6 (5) DOI: 10.1128/mBio.01289-15
Solans L., Uranga S., Aguilo N., Arnal C., Gomez A.B., Monzon M., Badiola J.J., Gicquel B., Martin C., Hyper-attenuated MTBVAC erp mutant protects against tuberculosis in mice, 2014, Vaccine, Vol 32 (40), DOI: 10.1016/j.vaccine.2014.07.047
Gonzalo-Asensio J., Malaga W., Pawlik A., Astarie-Dequeker C., Passemar C., Moreau F., Laval F., Daffé M., Martin C., Brosch R., Guilhot C., Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator, 2014, Proceedings of the National Academy of Sciences of the United States of America, Vol 111(31), DOI: 10.1073/pnas.1406693111
Aguiló N., Uranga S., Marinova D., Martín C., Pardo J., Bim is a crucial regulator of apoptosis induced by Mycobacterium tuberculosis, 2014, Cell Death and Disease, Vol 5 (7) DOI: 10.1038/cddis.2014.313
Solans L., Aguiló N., Samper S., Pawlik A., Frigui W., Martín C., Brosch R., Gonzalo-Asensio J. A., Specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies whiB6 as a novel ESX-1 component, 2014, Infection and Immunity, Vol 82 (8)
Solans L., Gonzalo-Asensio J., Sala C., Benjak A., Uplekar S., Rougemont J., Guilhot C., Malaga W., Martín C., Cole S.T., The PhoP-Dependent ncRNA Mcr7 Modulates the TAT Secretion System in Mycobacterium tuberculosis, 2014, PLoS Pathogens, Vol 10 (5) DOI: 10.1371/journal.ppat.1004183
Aguilo N., Toledo A.M., Lopez-Roman E.M., Perez-Herran E., Gormley E., Rullas-Trincado J., Angulo-Barturen I., Martin C., Pulmonary Mycobacterium bovis BCG vaccination confers dose-dependent superior protection compared to that of subcutaneous vaccination,2014, Clinical and Vaccine Immunology, 21 (4) DOI: 10.1128/CVI.00700-13
Aguiló N., Marinova D., Martín C., Pardo J., ESX-1-induced apoptosis during mycobacterial infection: To be or not to be, that is the question, 2013 Frontiers in Cellular and Infection Microbiology, Vol 3 (DEC), DOI 10.3389/fcimb.2013.00088
Marinova D., Gonzalo-Asensio J., Aguilo N., Martin C., Recent developments in tuberculosis vaccines, 2013, Expert Review of Vaccines, Vol. 12 (12), DOI: 10.1586/14760584.2013.856765
Aguilo J.I., Alonso H., Uranga S., Marinova D., Arbués A., de Martino A., Anel A., Monzon M., Badiola J., Pardo J., Brosch R., Martin C., ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis, 2013, Cellular Microbiology, Vol 15 (12), DOI 10.1111/cmi.12169
Arbues A., Aguilo J.I., Gonzalo-Asensio J., Marinova D., Uranga S., Puentes E., Fernandez C., Parra A., Cardona P.J., Vilaplana C., Ausina V., Williams A., Clark S., Malaga W., Guilhot C., Gicquel B., Martin C., Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials, 2013, Vaccine, Vol. 31 (42), DOI:10.1016/j.vaccine.2013.07.051
Aporta A., Arbues A., Aguilo J.I., Monzon M., Badiola J.J., de Martino A., Ferrer N., Marinova D., Anel A., Martin C., Pardo J., Attenuated Mycobacterium tuberculosis SO2 Vaccine Candidate Is Unable to Induce Cell Death, 2012, PLoS ONE, Vol. 7(9), DOI: 10.1371/journal.pone.0045213
Nambiar J.K., Pinto R., Aguilo J.I., Takatsu K., Martin C., Britton W.J., Triccas J.A., Protective immunity afforded by attenuated, PhoP-deficient Mycobacterium tuberculosis is associated with sustained generation of CD4 + T-cell memory,2012, European Journal of Immunology, Vol. 42(2), DOI:10.1002/eji.201141903