{"id":3092,"date":"2023-02-22T11:56:00","date_gmt":"2023-02-22T10:56:00","guid":{"rendered":"https:\/\/genmico.unizar.es\/?page_id=3092"},"modified":"2023-02-22T11:59:24","modified_gmt":"2023-02-22T10:59:24","slug":"3092-2","status":"publish","type":"page","link":"https:\/\/genmico.unizar.es\/en\/d2amr-antimicrobials\/3092-2\/","title":{"rendered":"Publications"},"content":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/4&#8243; css=&#8221;.vc_custom_1610458272385{margin-top: -24px !important;}&#8221;][vc_column_text]<\/p>\n<aside id=\"enhancedtextwidget-3\" class=\"widget-odd widget-3 widget widget_text enhanced-text-widget\">\n<h3 class=\"widget-title\">ANTIMICROBIANOS<\/h3>\n<\/aside>\n<p>[\/vc_column_text][vc_wp_custommenu nav_menu=&#8221;33&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;]<h2 style=\"text-align:left;font-size:24px;line-height:28px;\" class=\"tm-custom-heading \" >Publications<\/h2>\n[vc_column_text]Nanotechnology-Based Targeted Drug Delivery: An Emerging Tool to Overcome Tuberculosis.<br \/>\nBaranyai Z, Soria-Carrera H, Alleva M, Mill\u00e1n-Placer AC, Luc\u00eda A, Mart\u00edn-Rap\u00fan R, A\u00ednsa JA, de la Fuente JM.<br \/>\nAdv. Therap. 2021; 4:2000113<br \/>\nDOI: 10.1002\/adtp.202000113<\/p>\n<p>In silico discovery and biological validation of ligands of FAD synthase, a promising new antimicrobial target.<br \/>\nLans I, Anoz-Carbonell E, Palacio-Rodr\u00edguez K, A\u00ednsa JA, Medina M, Cossio P.<br \/>\nPLoS Comput Biol. 2020 Aug 14;16(8):e1007898. doi: 10.1371\/journal.pcbi.1007898.<br \/>\nPMID: 32797038<\/p>\n<p>Co-delivery of free vancomycin and transcription factor decoy-nanostructured lipid carriers can enhance inhibition of methicillin resistant Staphylococcus aureus (MRSA).<br \/>\nHibbitts A, Luc\u00eda A, Serrano-Sevilla I, De Matteis L, McArthur M, de la Fuente JM, A\u00ednsa JA, Navarro F.<br \/>\nPLoS One. 2019 Sep 3;14(9):e0220684. doi: 10.1371\/journal.pone.0220684.<br \/>\nPMID: 31479462<\/p>\n<p>Design, Synthesis, and Efficacy Testing of Nitroethylene- and 7-Nitrobenzoxadiazol-Based Flavodoxin Inhibitors against Helicobacter pylori Drug-Resistant Clinical Strains and in Helicobacter pylori-Infected Mice.<br \/>\nSalillas S, Al\u00edas M, Michel V, Mah\u00eda A, Luc\u00eda A, Rodrigues L, Bueno J, Galano-Frutos JJ, De Reuse H, Vel\u00e1zquez-Campoy A, Carrodeguas JA, Sostres C, Castillo J, A\u00ednsa JA, D\u00edaz-de-Villegas MD, Lanas \u00c1, Touati E, Sancho J.<br \/>\nJ Med Chem. 2019 Jul 11;62(13):6102-6115. doi: 10.1021\/acs.jmedchem.9b00355.<br \/>\nPMID: 31244111<\/p>\n<p>Mycobacterial Aminoglycoside Acetyltransferases: A Little of Drug Resistance, and a Lot of Other Roles.<br \/>\nSanz-Garc\u00eda F, Anoz-Carbonell E, P\u00e9rez-Herr\u00e1n E, Mart\u00edn C, Luc\u00eda A, Rodrigues L, A\u00ednsa JA.<br \/>\nFront Microbiol. 2019 Jan 30;10:46. doi: 10.3389\/fmicb.2019.00046.<br \/>\nPMID: 30761098<\/p>\n<p>Matryoshka-type gastro-resistant microparticles for the oral treatment of Mycobacterium tuberculosis.<br \/>\nAndreu V, Larrea A, Rodriguez-Fernandez P, Alfaro S, Gracia B, Luc\u00eda A, Us\u00f3n L, Gomez AC, Mendoza G, Lacoma A, Dominguez J, Prat C, Sebastian V, A\u00ednsa JA, Arruebo M.<br \/>\nNanomedicine (Lond). 2019 Mar;14(6):707-726. doi: 10.2217\/nnm-2018-0258.<br \/>\nPMID: 30734643<\/p>\n<p>Polypeptidic Micelles Stabilized with Sodium Alginate Enhance the Activity of Encapsulated Bedaquiline.<br \/>\nSoria-Carrera H, Luc\u00eda A, De Matteis L, A\u00ednsa JA, de la Fuente JM, Mart\u00edn-Rap\u00fan R.<br \/>\nMacromol Biosci. 2019 Apr;19(4):e1800397. doi: 10.1002\/mabi.201800397.<br \/>\nPMID: 30645022<\/p>\n<p>Synthesis and biological activity of dehydrophos derivatives.<br \/>\nJim\u00e9nez-Andreu MM, Luc\u00eda Quintana A, A\u00ednsa JA, Sayago FJ, Cativiela C.<br \/>\nOrg Biomol Chem. 2019 Jan 31;17(5):1097-1112. doi: 10.1039\/c8ob03079k.<br \/>\nPMID: 30633297<\/p>\n<p>New active formulations against M. tuberculosis: Bedaquiline encapsulation in lipid nanoparticles and chitosan nanocapsules.<br \/>\nDe Matteis L, Jary D, Luc\u00eda A, Garc\u00eda-Embid S, Serrano-Sevilla I, P\u00e9rez D, A\u00ednsa JA, Navarro FP, de la Fuente JM.<br \/>\nChemical Engineering Journal. 2018 May;340: 181-191. https:\/\/doi.org\/10.1016\/j.cej.2017.12.110<\/p>\n<p>The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase.<br \/>\nMori G, Orena BS, Franch C, Mitchenall LA, Godbole AA, Rodrigues L, Aguilar-P\u00e9rez C, Zemanov\u00e1 J, Husz\u00e1r S, Forbak M, Lane TR, Sabbah M, Deboosere N, Frita R, Vandeputte A, Hoffmann E, Russo R, Connell N, Veilleux C, Jha RK, Kumar P, Freundlich JS, Brodin P, A\u00ednsa JA, Nagaraja V, Maxwell A, Miku\u0161ov\u00e1 K, Pasca MR, Ekins S.<br \/>\nTuberculosis (Edinb). 2018 Sep;112:98-109. doi: 10.1016\/j.tube.2018.08.004.<br \/>\nPMID: 30205975<\/p>\n<p>Boldine-Derived Alkaloids Inhibit the Activity of DNA Topoisomerase I and Growth of Mycobacterium tuberculosis.<br \/>\nGarc\u00eda MT, Carre\u00f1o D, Tirado-V\u00e9lez JM, Ferr\u00e1ndiz MJ, Rodrigues L, Gracia B, Amblar M, A\u00ednsa JA, de la Campa AG.<br \/>\nFront Microbiol. 2018 Jul 24;9:1659. doi: 10.3389\/fmicb.2018.01659.<br \/>\nPMID: 30087665<\/p>\n<p>Synergy between Circular Bacteriocin AS-48 and Ethambutol against Mycobacterium tuberculosis.<br \/>\nAguilar-P\u00e9rez C, Gracia B, Rodrigues L, Vitoria A, Cebri\u00e1n R, Deboos\u00e8re N, Song OR, Brodin P, Maqueda M, A\u00ednsa JA.<br \/>\nAntimicrob Agents Chemother. 2018 Aug 27;62(9):e00359-18. doi: 10.1128\/AAC.00359-18.<br \/>\nPMID: 29987141<\/p>\n<p>Total Synthesis of Ripostatin B and Structure-Activity Relationship Studies on Ripostatin Analogs.<br \/>\nGlaus F, Dedi\u0107 D, Tare P, Nagaraja V, Rodrigues L, A\u00ednsa JA, Kunze J, Schneider G, Hartkoorn RC, Cole ST, Altmann KH.<br \/>\nJ Org Chem. 2018 Jul 6;83(13):7150-7172. doi: 10.1021\/acs.joc.8b00193.<br \/>\nPMID: 29542926<\/p>\n<p>Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors.<br \/>\nSong L, Merceron R, Gracia B, Quintana AL, Risseeuw MDP, Hulpia F, Cos P, A\u00ednsa JA, Munier-Lehmann H, Savvides SN, Van Calenbergh S.<br \/>\nJ Med Chem. 2018 Apr 12;61(7):2753-2775. doi: 10.1021\/acs.jmedchem.7b01570.<br \/>\nPMID: 29510037<\/p>\n<p>Discovery of antimicrobial compounds targeting bacterial type FAD synthetases.<br \/>\nSebasti\u00e1n M, Anoz-Carbonell E, Gracia B, Cossio P, A\u00ednsa JA, Lans I, Medina M.<br \/>\nJ Enzyme Inhib Med Chem. 2018 Dec;33(1):241-254. doi: 10.1080\/14756366.2017.1411910.<br \/>\nPMID: 29258359<\/p>\n<p>Ionophore A23187 shows anti-tuberculosis activity and synergy with tebipenem.<br \/>\nHuang W, Briffotaux J, Wang X, Liu L, Hao P, Cimino M, Buchieri MV, Namouchi A, A\u00ednsa JA, Gicquel B.<br \/>\nTuberculosis (Edinb). 2017 Dec;107:111-118. doi: 10.1016\/j.tube.2017.09.001.<br \/>\nPMID: 29050757<\/p>\n<p>How can nanoparticles contribute to antituberculosis therapy?<br \/>\nCosta-Gouveia J, A\u00ednsa JA, Brodin P, Luc\u00eda A.<br \/>\nDrug Discov Today. 2017 Mar;22(3):600-607. doi: 10.1016\/j.drudis.2017.01.011.<br \/>\nPMID: 28137645<\/p>\n<p>Antituberculosis drugs: reducing efflux=increasing activity.<br \/>\nRodrigues L, Parish T, Balganesh M, A\u00ednsa JA.<br \/>\nDrug Discov Today. 2017 Mar;22(3):592-599. doi: 10.1016\/j.drudis.2017.01.002.<br \/>\nPMID: 28089787<\/p>\n<p>Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions.<br \/>\nLiu J, Bruhn DF, Lee RB, Zheng Z, Janusic T, Scherbakov D, Scherman MS, Boshoff HI, Das S, Rakesh, Waidyarachchi SL, Brewer TA, Gracia B, Yang L, Bollinger J, Robertson GT, Meibohm B, Lenaerts AJ, A\u00ednsa J, B\u00f6ttger EC, Lee RE.<br \/>\nACS Infect Dis. 2017 Jan 13;3(1):72-88. doi: 10.1021\/acsinfecdis.6b00158.<br \/>\nPMID: 28081607<\/p>\n<p>Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria.<br \/>\nSingh V, Dhar N, Pat\u00f3 J, Kolly GS, Kordul\u00e1kov\u00e1 J, Forbak M, Evans JC, Sz\u00e9kely R, Rybniker J, Pal\u010dekov\u00e1 Z, Zemanov\u00e1 J, Santi I, Signorino-Gelo F, Rodrigues L, Vocat A, Covarrubias AS, Rengifo MG, Johnsson K, Mowbray S, Buechler J, Delorme V, Brodin P, Knott GW, A\u00ednsa JA, Warner DF, K\u00e9ri G, Miku\u0161ov\u00e1 K, McKinney JD, Cole ST, Mizrahi V, Hartkoorn RC.<br \/>\nMol Microbiol. 2017 Jan;103(1):13-25. doi: 10.1111\/mmi.13535.<br \/>\nPMID: 27677649<\/p>\n<p>Lipid transport in Mycobacterium tuberculosis and its implications in virulence and drug development.<br \/>\nBailo R, Bhatt A, A\u00ednsa JA.<br \/>\nBiochem Pharmacol. 2015 Aug 1;96(3):159-67. doi: 10.1016\/j.bcp.2015.05.001.<br \/>\nPMID: 25986884<\/p>\n<p>Measuring efflux and permeability in mycobacteria.<br \/>\nRodrigues L, Viveiros M, A\u00ednsa JA.<br \/>\nMethods Mol Biol. 2015;1285:227-39. doi: 10.1007\/978-1-4939-2450-9_13.<br \/>\nPMID: 25779319<\/p>\n<p>Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux.<br \/>\nLee RE, Hurdle JG, Liu J, Bruhn DF, Matt T, Scherman MS, Vaddady PK, Zheng Z, Qi J, Akbergenov R, Das S, Madhura DB, Rathi C, Trivedi A, Villellas C, Lee RB, Rakesh, Waidyarachchi SL, Sun D, McNeil MR, A\u00ednsa JA, Boshoff HI, Gonzalez-Juarrero M, Meibohm B, B\u00f6ttger EC, Lenaerts AJ.<br \/>\nNat Med. 2014 Feb;20(2):152-158. doi: 10.1038\/nm.3458.<br \/>\nPMID: 24464186<\/p>\n<p>Analysis of mutations in streptomycin-resistant strains reveals a simple and reliable genetic marker for identification of the Mycobacterium tuberculosis Beijing genotype.<br \/>\nVillellas C, Aristimu\u00f1o L, Vitoria MA, Prat C, Blanco S, Garc\u00eda de Viedma D, Dom\u00ednguez J, Samper S, A\u00ednsa JA.<br \/>\nJ Clin Microbiol. 2013 Jul;51(7):2124-30. doi: 10.1128\/JCM.01944-12.<br \/>\nPMID: 23616454<\/p>\n<p>Zanthoxylum capense constituents with antimycobacterial activity against Mycobacterium tuberculosis in vitro and ex vivo within human macrophages.<br \/>\nLuo X, Pires D, A\u00ednsa JA, Gracia B, Duarte N, Mulhovo S, Anes E, Ferreira MJ.<br \/>\nJ Ethnopharmacol. 2013 Mar 7;146(1):417-22. doi: 10.1016\/j.jep.2013.01.013.<br \/>\nPMID: 23337743<\/p>\n<p>Role of the Mmr efflux pump in drug resistance in Mycobacterium tuberculosis.<br \/>\nRodrigues L, Villellas C, Bailo R, Viveiros M, A\u00ednsa JA.<br \/>\nAntimicrob Agents Chemother. 2013 Feb;57(2):751-7. doi: 10.1128\/AAC.01482-12.<br \/>\nPMID: 23165464<\/p>\n<p>Inhibitors of mycobacterial efflux pumps as potential boosters for anti-tubercular drugs.<br \/>\nViveiros M, Martins M, Rodrigues L, Machado D, Couto I, A\u00ednsa J, Amaral L.<br \/>\nExpert Rev Anti Infect Ther. 2012 Sep;10(9):983-98. doi: 10.1586\/eri.12.89.<br \/>\nPMID: 23106274<\/p>\n<p>Mycobacterial shuttle vectors designed for high-level protein expression in infected macrophages.<br \/>\nEitson JL, Medeiros JJ, Hoover AR, Srivastava S, Roybal KT, A\u00ednsa JA, Hansen EJ, Gumbo T, van Oers NS.<br \/>\nAppl Environ Microbiol. 2012 Oct;78(19):6829-37. doi: 10.1128\/AEM.01674-12.<br \/>\nPMID: 22820329<\/p>\n<p>Functional and genetic characterization of the tap efflux pump in Mycobacterium bovis BCG.<br \/>\nRam\u00f3n-Garc\u00eda S, Mick V, Dainese E, Mart\u00edn C, Thompson CJ, De Rossi E, Manganelli R, A\u00ednsa JA.<br \/>\nAntimicrob Agents Chemother. 2012 Apr;56(4):2074-83. doi: 10.1128\/AAC.05946-11.<br \/>\nPMID: 22232275<\/p>\n<p>A prodrug approach for improving antituberculosis activity of potent Mycobacterium tuberculosis type II dehydroquinase inhibitors.<br \/>\nTiz\u00f3n L, Otero JM, Prazeres VF, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, A\u00ednsa JA, Castedo L, Gonz\u00e1lez-Bello C.<br \/>\nJ Med Chem. 2011 Sep 8;54(17):6063-84. doi: 10.1021\/jm2006063.<br \/>\nPMID: 21780742<\/p>\n<p>Antimycobacterial evaluation and preliminary phytochemical investigation of selected medicinal plants traditionally used in Mozambique.<br \/>\nLuo X, Pires D, A\u00ednsa JA, Gracia B, Mulhovo S, Duarte A, Anes E, Ferreira MJ.<br \/>\nJ Ethnopharmacol. 2011 Sep 1;137(1):114-20. doi: 10.1016\/j.jep.2011.04.062.<br \/>\nPMID: 21571059<\/p>\n<p>Inhibition of drug efflux in mycobacteria with phenothiazines and other putative efflux inhibitors.<br \/>\nRodrigues L, A\u00ednsa JA, Amaral L, Viveiros M.<br \/>\nRecent Pat Antiinfect Drug Discov. 2011 May;6(2):118-27. doi: 10.2174\/157489111796064579.<br \/>\nPMID: 21517739<\/p>\n<p>Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone.<br \/>\nFamiliar O, Munier-Lehmann H, A\u00ednsa JA, Camarasa MJ, P\u00e9rez-P\u00e9rez MJ.<br \/>\nEur J Med Chem. 2010 Dec;45(12):5910-8. doi: 10.1016\/j.ejmech.2010.09.056.<br \/>\nPMID: 20951473<\/p>\n<p>The complex whiJ locus mediates environmentally sensitive repression of development of Streptomyces coelicolor A3(2).<br \/>\nA\u00ednsa JA, Bird N, Ryding NJ, Findlay KC, Chater KF.<br \/>\nAntonie Van Leeuwenhoek. 2010 Aug;98(2):225-36. doi: 10.1007\/s10482-010-9443-3.<br \/>\nPMID: 20405209<\/p>\n<p>Role of the Mycobacterium tuberculosis P55 efflux pump in intrinsic drug resistance, oxidative stress responses, and growth.<br \/>\nRam\u00f3n-Garc\u00eda S, Mart\u00edn C, Thompson CJ, A\u00ednsa JA.<br \/>\nAntimicrob Agents Chemother. 2009 Sep;53(9):3675-82. doi: 10.1128\/AAC.00550-09.<br \/>\nPMID: 19564371<\/p>\n<p>Transcriptional analysis of and resistance level conferred by the aminoglycoside acetyltransferase gene aac(2&#8242;)-Id from Mycobacterium smegmatis.<br \/>\nMick V, Rebollo MJ, Luc\u00eda A, Garc\u00eda MJ, Mart\u00edn C, A\u00ednsa JA.<br \/>\nJ Antimicrob Chemother. 2008 Jan;61(1):39-45. doi: 10.1093\/jac\/dkm440.<br \/>\nPMID: 18032424<\/p>\n<p>Contribution of the Rv2333c efflux pump (the Stp protein) from Mycobacterium tuberculosis to intrinsic antibiotic resistance in Mycobacterium bovis BCG.<br \/>\nRam\u00f3n-Garc\u00eda S, Mart\u00edn C, De Rossi E, A\u00ednsa JA.<br \/>\nJ Antimicrob Chemother. 2007 Mar;59(3):544-7. doi: 10.1093\/jac\/dkl510.<br \/>\nPMID: 17242035<\/p>\n<p>Novel streptomycin resistance gene from Mycobacterium fortuitum.<br \/>\nRam\u00f3n-Garc\u00eda S, Otal I, Mart\u00edn C, G\u00f3mez-Lus R, A\u00ednsa JA.<br \/>\nAntimicrob Agents Chemother. 2006 Nov;50(11):3920-2. doi: 10.1128\/AAC.00223-06.<br \/>\nPMID: 16954315<\/p>\n<p>Role of mycobacterial efflux transporters in drug resistance: an unresolved question.<br \/>\nDe Rossi E, A\u00ednsa JA, Riccardi G.<br \/>\nFEMS Microbiol Rev. 2006 Jan;30(1):36-52. doi: 10.1111\/j.1574-6976.2005.00002.x.<br \/>\nPMID: 16438679<\/p>\n<p>Characterization of tetracycline resistance mediated by the efflux pump Tap from Mycobacterium fortuitum.<br \/>\nRam\u00f3n-Garc\u00eda S, Mart\u00edn C, A\u00ednsa JA, De Rossi E.<br \/>\nJ Antimicrob Chemother. 2006 Feb;57(2):252-9. doi: 10.1093\/jac\/dki436.<br \/>\nPMID: 16373429<\/p>\n<p>The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis.<br \/>\nDe Rossi E, Arrigo P, Bellinzoni M, Silva PA, Mart\u00edn C, A\u00ednsa JA, Guglierame P, Riccardi G.<br \/>\nMol Med. 2002 Nov;8(11):714-24.<br \/>\nPMID: 12520088<\/p>\n<p>Molecular approaches to tuberculosis.<br \/>\nA\u00ednsa JA, Mart\u00edn C, Gicquel B.<br \/>\nMol Microbiol. 2001 Oct;42(2):561-70. doi: 10.1046\/j.1365-2958.2001.02652.x.<br \/>\nPMID: 11703676<\/p>\n<p>Characterization of P55, a multidrug efflux pump in Mycobacterium bovis and Mycobacterium tuberculosis.<br \/>\nSilva PE, Bigi F, Santangelo MP, Romano MI, Mart\u00edn C, Cataldi A, A\u00ednsa JA.<br \/>\nAntimicrob Agents Chemother. 2001 Mar;45(3):800-4. doi: 10.1128\/AAC.45.3.800-804.2001.<br \/>\nPMID: 11181364<\/p>\n<p>WhiA, a protein of unknown function conserved among gram-positive bacteria, is essential for sporulation in Streptomyces coelicolor A3(2).<br \/>\nA\u00ednsa JA, Ryding NJ, Hartley N, Findlay KC, Bruton CJ, Chater KF.<br \/>\nJ Bacteriol. 2000 Oct;182(19):5470-8. doi: 10.1128\/jb.182.19.5470-5478.2000.<br \/>\nPMID: 10986251<\/p>\n<p>A response regulator-like protein that functions at an intermediate stage of sporulation in Streptomyces coelicolor A3(2).<br \/>\nA\u00ednsa JA, Parry HD, Chater KF.<br \/>\nMol Microbiol. 1999 Nov;34(3):607-19. doi: 10.1046\/j.1365-2958.1999.01630.x.<br \/>\nPMID: 10564501<\/p>\n<p>Molecular cloning and characterization of Tap, a putative multidrug efflux pump present in Mycobacterium fortuitum and Mycobacterium tuberculosis.<br \/>\nA\u00ednsa JA, Blokpoel MC, Otal I, Young DB, De Smet KA, Mart\u00edn C.<br \/>\nJ Bacteriol. 1998 Nov;180(22):5836-43. doi: 10.1128\/JB.180.22.5836-5843.1998.<br \/>\nPMID: 9811639<\/p>\n<p>katGI and katGII encode two different catalases-peroxidases in Mycobacterium fortuitum.<br \/>\nMen\u00e9ndez MC, A\u00ednsa JA, Mart\u00edn C, Garc\u00eda MJ.<br \/>\nJ Bacteriol. 1997 Nov;179(22):6880-6. doi: 10.1128\/jb.179.22.6880-6886.1997.<br \/>\nPMID: 9371430<\/p>\n<p>Isolation by genetic labeling of a new mycobacterial plasmid, pJAZ38, from Mycobacterium fortuitum.<br \/>\nGavigan JA, A\u00ednsa JA, P\u00e9rez E, Otal I, Mart\u00edn C.<br \/>\nJ Bacteriol. 1997 Jul;179(13):4115-22. doi: 10.1128\/jb.179.13.4115-4122.1997.<br \/>\nPMID: 9209023<\/p>\n<p>Aminoglycoside 2&#8242;-N-acetyltransferase genes are universally present in mycobacteria: characterization of the aac(2&#8242;)-Ic gene from Mycobacterium tuberculosis and the aac(2&#8242;)-Id gene from Mycobacterium smegmatis.<br \/>\nA\u00ednsa JA, P\u00e9rez E, Pelicic V, Berthet FX, Gicquel B, Mart\u00edn C.<br \/>\nMol Microbiol. 1997 Apr;24(2):431-41. doi: 10.1046\/j.1365-2958.1997.3471717.x.<br \/>\nPMID: 9159528<\/p>\n<p>Construction of a family of Mycobacterium\/Escherichia coli shuttle vectors derived from pAL5000 and pACYC184: their use for cloning an antibiotic-resistance gene from Mycobacterium fortuitum.<br \/>\nA\u00ednsa JA, Mart\u00edn C, Cabeza M, De la Cruz F, Mendiola MV.<br \/>\nGene. 1996 Oct 17;176(1-2):23-6. doi: 10.1016\/0378-1119(96)00202-8.<br \/>\nPMID: 8918226<\/p>\n<p>Characterization of the chromosomal aminoglycoside 2&#8242;-N-acetyltransferase gene from Mycobacterium fortuitum.<br \/>\nA\u00ednsa JA, Martin C, Gicquel B, Gomez-Lus R.<br \/>\nAntimicrob Agents Chemother. 1996 Oct;40(10):2350-5. doi: 10.1128\/AAC.40.10.2350.<br \/>\nPMID: 8891143[\/vc_column_text][vc_empty_space]<h2 style=\"text-align:left;font-size:24px;line-height:28px;\" class=\"tm-custom-heading \" >Cap\u00edtulos de libros<\/h2>\n[vc_column_text]J.A. Gonzalo Asensio; S. Samper Blasco; J.A. A\u00ednsa; I. Otal Gil; C. Mart\u00edn Monta\u00f1\u00e9s.<br \/>\nLos Retos de la Erradicaci\u00f3n de la Tuberculosis en el Siglo XXI.<br \/>\nEn: Aplicaci\u00f3n de la Biotecnolog\u00eda en la Ciencia Veterinaria. pp. 117 &#8211; 134. 2012. ISBN 978-84-7867-202-8<\/p>\n<p>P.E.A. Silva; J.A. A\u00ednsa.<br \/>\nDrugs and drug interactions.<br \/>\nEn: Tuberculosis 2007: From Basic Science to Patient Care. pp. 593 &#8211; 634. 2007.<br \/>\nBernd Sebastian Kamps (ed), <a href=\"http:\/\/www.tuberculosistextbook.com\">www.tuberculosistextbook.com<\/a><\/p>\n<p>J. Content; M. Braibant; N.D. Connel; J.A. A\u00ednsa.<br \/>\nTransport processes.<br \/>\nEn: Tuberculosis and the Tubercle Bacillus. pp. 379 &#8211; 401. 2004. ISBN 1-55581-295-3<br \/>\nST Cole, KD Eisenach, DN McMurray, WR Jacobs-Jr, (eds). American Society for Microbiology Press, Washington D.C., USA<\/p>\n<p>J.A. A\u00ednsa; C. Mart\u00edn.<br \/>\nMolecular basis of aminoglycoside resistance in Mycobacterium<br \/>\nEn: Recent Research Developments in Antimicrobial Agents &amp; Chemotherapy 4, (I): 1-10. 2000.<br \/>\nResearch Signpost, Trivandrum, India.[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/4&#8243; css=&#8221;.vc_custom_1610458272385{margin-top: -24px !important;}&#8221;][vc_column_text] ANTIMICROBIANOS [\/vc_column_text][vc_wp_custommenu nav_menu=&#8221;33&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text]Nanotechnology-Based Targeted Drug Delivery: An Emerging Tool to Overcome Tuberculosis. Baranyai Z, Soria-Carrera H, Alleva M, Mill\u00e1n-Placer AC, Luc\u00eda A, Mart\u00edn-Rap\u00fan R, A\u00ednsa JA, de la Fuente JM. Adv. Therap. 2021; 4:2000113 DOI: 10.1002\/adtp.202000113 In silico discovery and biological validation of ligands of FAD synthase, a promising &hellip; <a href=\"https:\/\/genmico.unizar.es\/en\/d2amr-antimicrobials\/3092-2\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Publications<\/span><\/a><\/p>\n","protected":false},"author":31,"featured_media":0,"parent":2874,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/genmico.unizar.es\/en\/wp-json\/wp\/v2\/pages\/3092"}],"collection":[{"href":"https:\/\/genmico.unizar.es\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/genmico.unizar.es\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/genmico.unizar.es\/en\/wp-json\/wp\/v2\/users\/31"}],"replies":[{"embeddable":true,"href":"https:\/\/genmico.unizar.es\/en\/wp-json\/wp\/v2\/comments?post=3092"}],"version-history":[{"count":4,"href":"https:\/\/genmico.unizar.es\/en\/wp-json\/wp\/v2\/pages\/3092\/revisions"}],"predecessor-version":[{"id":3096,"href":"https:\/\/genmico.unizar.es\/en\/wp-json\/wp\/v2\/pages\/3092\/revisions\/3096"}],"up":[{"embeddable":true,"href":"https:\/\/genmico.unizar.es\/en\/wp-json\/wp\/v2\/pages\/2874"}],"wp:attachment":[{"href":"https:\/\/genmico.unizar.es\/en\/wp-json\/wp\/v2\/media?parent=3092"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}