{"id":3083,"date":"2023-02-22T11:42:02","date_gmt":"2023-02-22T10:42:02","guid":{"rendered":"https:\/\/genmico.unizar.es\/?page_id=3083"},"modified":"2023-02-28T16:33:24","modified_gmt":"2023-02-28T15:33:24","slug":"publicaciones","status":"publish","type":"page","link":"https:\/\/genmico.unizar.es\/en\/evolution-and-vaccines\/publicaciones\/","title":{"rendered":"Publications"},"content":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/4&#8243; css=&#8221;.vc_custom_1610458272385{margin-top: -24px !important;}&#8221;][vc_column_text]<\/p>\n<aside id=\"enhancedtextwidget-3\" class=\"widget-odd widget-3 widget widget_text enhanced-text-widget\">\n<h3 class=\"widget-title\">VACCINES<\/h3>\n<\/aside>\n<p>[\/vc_column_text][vc_wp_custommenu nav_menu=&#8221;38&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;]<h2 style=\"text-align:left;font-size:24px;line-height:28px;\" class=\"tm-custom-heading \" ><\/h2>\n[vc_column_text]<span style=\"font-weight: 400;\">Moreo, E., Uranga, S., Pic\u00f3, A., G\u00f3mez, A.B., Nardelli-Haefliger, D., Del Fresno, C., Murillo, I., Puentes, E., Rodr\u00edguez, E., Vales-G\u00f3mez, M., Pardo, J., Sancho, D., Mart\u00edn, C., Aguilo, N., Novel intravesical bacterial immunotherapy induces rejection of BCG-unresponsive established bladder tumors, 2022, Journal for ImmunoTherapy of Cancer, vol 10 (7), DOI: 10.1136\/jitc-2021-004325.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">P\u00e9rez, I., Campos-Pardos, E., D\u00edaz, C., Uranga, S., Sayes, F., Vicente, F., Aguil\u00f3, N., Brosch, R., Mart\u00edn, C., Gonzalo-Asensio, J., The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy, 2022, Molecular Therapy &#8211; Nucleic Acids, Vol 27, DOI: 10.1016\/j.omtn.2022.02.011<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Mart\u00edn, C., Marinova, D., Aguil\u00f3, N., Gonzalo-Asensio, J., MTBVAC, a live TB vaccine poised to initiate efficacy trials 100 years after BCG, 2021, Vaccine, Vol 39(50), DOI: 10.1016\/j.vaccine.2021.06.049<\/span><\/p>\n<p><span style=\"font-weight: 400;\">White A.D., Sibley L., Sarfas C., Morrison A., Gullick J., Clark S., Gleeson F., McIntyre A., Arlehamn C.L., Sette A., Salguero F.J., Rayner E., Rodriguez E., Puentes E., Laddy D., Williams A., Dennis M., Martin C., Sharpe S., MTBVAC vaccination protects rhesus macaques against aerosol challenge with M. tuberculosis and induces immune signatures analogous to those observed in clinical studies, 2021, npj Vaccines, Vol 6(1) DOI: 10.1038\/s41541-020-00262-8<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Broset E., Pardo-Seco J., Kanno A.I., Aguilo N., Dacosta A.I., Rivero-Calle I., Gonzalo-Asensio J., Locht C., Leite L.C.C., Martin C., Martin\u00f3n-Torres F., BCG vaccination improves DTaP immune responses in mice and is associated with lower pertussis incidence in ecological epidemiological studies, 2021, EBioMedicine, Vol 65, DOI: 10.1016\/j.ebiom.2021.103254<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Broset E., Calvet Seral J., Arnal C., Uranga S., Kanno A.I., Leite L.C.C., Mart\u00edn C., Gonzalo-Asensio J., Engineering a new vaccine platform for heterologous antigen delivery in live-attenuated Mycobacterium tuberculosis, 2021,Computational and Structural Biotechnology Journal, Vol 19, DOI:10.1016\/j.csbj.2021.07.035<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Taranc\u00f3n R., Mata E., Uranga S., G\u00f3mez A.B., Marinova D., Otal I., Mart\u00edn C., Aguil\u00f3 N., Therapeutic efficacy of pulmonary live tuberculosis vaccines against established asthma by subverting local immune environment, 2021, EBioMedicine, Vol 64,DOI: 10.1016\/j.ebiom.2020.103186<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Dijkman K., Aguilo N., Boot C., Hofman S.O., Sombroek C.C., Vervenne R.A.W., Kocken C.H.M., Marinova D., Thole J., Rodr\u00edguez E., Vierboom M.P.M., Haanstra K.G., Puentes E., Martin C., Verreck F.A.W.,\u00a0 Pulmonary MTBVAC vaccination induces immune signatures previously correlated with prevention of tuberculosis infection, 2021, Cell Reports Medicine, DOI: 10.1016\/j.xcrm.2020.100187<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Vierboom M.P.M., Dijkman K., Sombroek C.C., Hofman S.O., Boot C., Vervenne R.A.W., Haanstra K.G., van der Sande M., van Emst L., Dom\u00ednguez-Andr\u00e9s J., Moorlag S.J.C.F.M., Kocken C.H.M., Thole J., Rodr\u00edguez E., Puentes E., Martens J.H.A., van Crevel R., Netea M.G., Aguilo N., Martin C., Verreck F.A.W., Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination, 2021, Cell Reports Medicine, Vol 2 (1), DOI: 10.1016\/j.xcrm.2020.100185<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Mata E., Tarancon R., Guerrero C., Moreo E., Moreau F., Uranga S., Gomez A.B., Marinova D., Domenech M., Gonzalez-Camacho F., Monzon M., Badiola J., Dominguez-Andres J., Yuste J., Anel A., Peixoto A., Martin C., Aguilo N., Pulmonary BCG induces lung-resident macrophage activation and confers long-term protection against tuberculosis, 2021, Science Immunology, Vol 6 (66) DOI: 10.1126\/sciimmunol.abc2934<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Mata E., Farrell D., Ma R., Uranga S., Gomez A.B., Monzon M., Badiola J., Anel A., Gonzalo-Asensio J., Martin C., Gordon S.V., Aguilo N., Independent genomic polymorphisms in the PknH serine threonine kinase locus during evolution of the Mycobacterium tuberculosis Complex affect virulence and host preference, 2020, PLoS Pathogens, Vol 16 (12) DOI: 10.1371\/journal.ppat.1009061<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Aguilo N., Uranga S., Mata E., Tarancon R., G\u00f3mez A.B., Marinova D., Otal I., Monz\u00f3n M., Badiola J., Montenegro D., Puentes E., Rodr\u00edguez E., Vervenne R.A.W., Sombroek C.C., Verreck F.A.W., Mart\u00edn C., Respiratory Immunization With a Whole Cell Inactivated Vaccine Induces Functional Mucosal Immunoglobulins Against Tuberculosis in Mice and Non-human Primates, 2020, Frontiers in Microbiology, Vol 11, DOI: 10.3389\/fmicb.2020.01339<\/span><\/p>\n<p><span style=\"font-weight: 400;\">P\u00e9rez I., Uranga S., Sayes F., Frigui W., Samper S., Arbu\u00e9s A., Aguil\u00f3 N., Brosch R., Mart\u00edn C., Gonzalo-Asensio J., Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro\u2013American genetic background confers optimal vaccine potential, 2020,EBioMedicine, Vol 55, DOI 10.1016\/j.ebiom.2020.102761<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Martin C., Aguilo N., Marinova D., Gonzalo-Asensio J., Update on TB vaccine pipeline, 2020, Applied Sciences (Switzerland), Vol 10 (7), 10.3390\/app10072632<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Taranc\u00f3n R., Dom\u00ednguez-Andr\u00e9s J., Uranga S., Ferreira A.V., Groh L.A., Domenech M., Gonz\u00e1lez-Camacho F., Riksen N.P., Aguilo N., Yuste J., Mart\u00edn C., Netea M.G., New live attenuated tuberculosis vaccine MTBVAC induces trained immunity and confers protection against experimental lethal pneumonia, 2020, PLoS Pathogens, Vol 16 (4), DOI: 10.1371\/journal.ppat.1008404<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tovar M., Arregui S., Marinova D., Mart\u00edn C., Sanz J., Moreno Y., Bridging the gap between efficacy trials and model-based impact evaluation for new tuberculosis vaccines, 2019, Nature Communications, Vol 10 (1) DOI: 10.1038\/s41467-019-13387-9<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Taranc\u00f3n R., Uranga S., Mart\u00edn C., Aguil\u00f3 N., Mycobacterium tuberculosis infection prevents asthma and abrogates eosinophilopoiesis in an experimental model, 2019, Allergy: European Journal of Allergy and Clinical Immunology, Vol 74 (12), DOI:\u00a0 10.1111\/all.13923<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Taranc\u00f3n R., Uranga S., Mart\u00edn C., Aguil\u00f3 N., Mycobacterium tuberculosis infection prevents asthma and abrogates eosinophilopoiesis in an experimental model, 2019, Allergy: European Journal of Allergy and Clinical Immunology, Vol 74(12) DOI: 10.1111\/all.13923<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Tameris M., Mearns H., Penn-Nicholson A., Gregg Y., Bilek N., Mabwe S., Geldenhuys H., Shenje J., Luabeya A.K.K., Murillo I., Doce J., Aguilo N., Marinova D., Puentes E., Rodr\u00edguez E., Gonzalo-Asensio J., Fritzell B., Thole J., Martin C., Scriba T.J., Hatherill M., Africa H., Arendsen D., Botes N., Cloete Y., De Kock M., Erasmus M., Jack L., Kafaar F., Kalepu X., Khomba N.G., Kruger S., Leopeng T., Makhethe L., Mouton A., Mulenga H., Musvosvi M., Noble J., Opperman F., Reid T., Rossouw S., Schreuder C., Smit E., Steyn M., Tyambethu P., Van Rooyen E., Veldsman A., MTBVAC Clinical Trial Team, Live-attenuated Mycobacterium tuberculosis vaccine MTBVAC versus BCG in adults and neonates: a randomised controlled, double-blind dose-escalation trial,2019, The Lancet Respiratory Medicine, Vol 7(9)DOI: 10.1016\/S2213-2600(19)30251-6<\/span><\/p>\n<p><span style=\"font-weight: 400;\">D\u00edaz C., P\u00e9rez Del Palacio J., Valero-Guill\u00e9n P.L., Mena Garc\u00eda P., P\u00e9rez I., Vicente F., Mart\u00edn C., Genilloud O., S\u00e1nchez Pozo A., Gonzalo-Asensio J., Comparative Metabolomics between Mycobacterium tuberculosis and the MTBVAC Vaccine Candidate, 2019, ACS Infectious Diseases, Vol 5(8), 10.1021\/acsinfecdis.9b00008<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Broset E., Saubi N., Guitart N., Aguilo N., Uranga S., Kilpel\u00e4inen A., Eto Y., Hanke T., Gonzalo-Asensio J., Mart\u00edn C., Joseph-Munn\u00e9 J., MTBVAC-Based TB-HIV Vaccine Is Safe, Elicits HIV-T Cell Responses, and Protects against Mycobacterium tuberculosis in Mice,2019, Molecular Therapy &#8211; Methods and Clinical Development, Vol 13, DOI: 10.1016\/j.omtm.2019.01.014<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Gonzalo-Asensio J., Aguilo N., Marinova D., Martin C., Breaking transmission with vaccines: The case of tuberculosis, 2019, Microbial Transmission, DOI: 10.1128\/9781555819743.ch14<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u200b\u200bMartin C., Aguilo N., Gonzalo-Asensio J., Vaccination against tuberculosis [Vacunaci\u00f3n frente a tuberculosis]2018, Enfermedades Infecciosas y Microbiologia Clinica, Vol 36 (10) DOI: 10.1016\/j.eimc.2018.02.006<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Alvarez-Arguedas S., Uranga S., Mart\u00edn M., Elizalde J., Gomez A.B., Juli\u00e1n E., Nardelli-Haefliger D., Mart\u00edn C., Aguilo N., Therapeutic efficacy of the live-attenuated Mycobacterium tuberculosis vaccine, MTBVAC, in a preclinical model of bladder cancer, 2018, Translational Research, Vol 197, 10.1016\/j.trsl.2018.03.004<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Arregui S., Iglesias M.J., Samper S., Marinova D., Martin C., Sanz J., Moreno Y., Data-driven model for the assessment of mycobacterium tuberculosis transmission in evolving demographic structures,2018, Proceedings of the National Academy of Sciences of the United States of America, Vol 115 (14) DOI: 10.1073\/pnas.1720606115<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Gonzalo-Asensio J., P\u00e9rez I., Aguil\u00f3 N., Uranga S., Pic\u00f3 A., Lampreave C., Cebollada A., Otal I., Samper S., Mart\u00edn C., New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages, 2018, PLoS Genetics, Vol 14 (4)DOI: 10.1371\/journal.pgen.1007282<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Gonzalo-Asensio J., Marinova D., Martin C., Aguilo N., MTBVAC: Attenuating the human pathogen of tuberculosis (TB) toward a promising vaccine against the TB epidemic, 2017, Frontiers in Immunology, Vol 8 (DEC), DOI: 10.3389\/fimmu.2017.01803<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Clark S., Lanni F., Marinova D., Rayner E., Martin C., Williams A., Revaccination of Guinea pigs with the live attenuated Mycobacterium tuberculosis vaccine MTBVAC improves BCG&#8217;s protection against tuberculosis, 2017, Journal of Infectious Diseases, Vol 216 (5)DOI: 10.1093\/infdis\/jix030<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Aguilo N., Gonzalo-Asensio J., Alvarez-Arguedas S., Marinova D., Gomez A.B., Uranga S., Spallek R., Singh M., Audran R., Spertini F., Martin C., Revaccination of Guinea pigs with the live attenuated Mycobacterium tuberculosis vaccine MTBVAC improves BCG&#8217;s protection against tuberculosis, 2017, Nature Communications, Vol 8, DOI: 10.1038\/ncomms16085<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Gonzalo-Asensio J., Aguilo N., Marinova D., Martin C., Breaking transmission with vaccines: The case of tuberculosis, 2017, Microbiology Spectrum Vol 5(4)DOI: 10.1128\/microbiolspec.MTBP-0001-2016<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Marinova D., Gonzalo-Asensio J., Aguilo N., Martin C., MTBVAC from discovery to clinical trials in tuberculosis-endemic countries, 2017, Expert Review of Vaccines, Vol. 16(6) DOI 10.1080\/14760584.2017.1324303<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Uranga S., Marinova D., Martin C., Aguilo N., Protective efficacy and pulmonary immune response following subcutaneous and intranasal BCG administration in mice, 2016, Journal of Visualized Experiments, 2016, DOI: 10.3791\/54440<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Uranga S., Marinova D., Martin C., Pardo J., Aguilo N., Granzyme a is expressed in mouse lungs during mycobacterium tuberculosis infection but does not contribute to protection in vivo, 2016, PLoS ONE, Vol. 11(4) DOI: 10.1371\/journal.pone.0153028<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Scriba T.J., Kaufmann S.H.E., Lambert P.H., Sanicas M., Martin C., Neyrolles O., Vaccination against tuberculosis with whole-cell mycobacterial vaccines, 2016, Journal of Infectious Diseases, Vol 214 (5) DOI: 10.1093\/infdis\/jiw228<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Arregui S., Sanz J., Marinova D., Mart\u00edn C., Moreno Y., On the impact of masking and blocking hypotheses for measuring the efficacy of new tuberculosis vaccines, 2016, PeerJ, Vol. 2016 (2), DOI: 10.7717\/peerj.1513<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Aguilo N., Uranga S., Marinova D., Monzon M., Badiola J., Martin C., MTBVAC vaccine is safe, immunogenic and confers protective efficacy against Mycobacterium tuberculosis in newborn mice, 2016, Tuberculosis, Vol. 96, 10.1016\/j.tube.2015.10.010<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Aguilo N., Alvarez-Arguedas S., Uranga S., Marinova D., Monz\u00f3n M., Badiola J., Martin C., Pulmonary but not subcutaneous delivery of BCG vaccine confers protection to tuberculosis-susceptible mice by an interleukin 17-dependent mechanism, 2015, Journal of Infectious Diseases, Vol 212 (11), DOI: 10.1093\/infdis\/jiv503<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Spertini F., Audran R., Chakour R., Karoui O., Steiner-Monard V., Thierry A.-C., Mayor C.E., Rettby N., Jaton K., Vallotton L., Lazor-Blanchet C., Doce J., Puentes E., Marinova D., Aguilo N., Martin C., Safety of human immunisation with a live-attenuated Mycobacterium tuberculosis vaccine: A randomised, double-blind, controlled phase I trial, 2015, The Lancet Respiratory Medicine, Vol 3(12), 10.1016\/S2213-2600(15)00435-X<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Broset E., Mart\u00edn C., Gonzalo-Asensio J., Evolutionary landscape of the mycobacterium tuberculosis complex from the viewpoint of phoPR: Implications for virulence regulation and application to vaccine development, 2015, mBio, Vol. 6 (5) DOI: 10.1128\/mBio.01289-15<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Solans L., Uranga S., Aguilo N., Arnal C., Gomez A.B., Monzon M., Badiola J.J., Gicquel B., Martin C., Hyper-attenuated MTBVAC erp mutant protects against tuberculosis in mice, 2014, Vaccine, Vol 32 (40), DOI: 10.1016\/j.vaccine.2014.07.047<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Gonzalo-Asensio J., Malaga W., Pawlik A., Astarie-Dequeker C., Passemar C., Moreau F., Laval F., Daff\u00e9 M., Martin C., Brosch R., Guilhot C., Evolutionary history of tuberculosis shaped by conserved mutations in the PhoPR virulence regulator, 2014, Proceedings of the National Academy of Sciences of the United States of America, Vol 111(31), DOI: 10.1073\/pnas.1406693111<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Aguil\u00f3 N., Uranga S., Marinova D., Mart\u00edn C., Pardo J., Bim is a crucial regulator of apoptosis induced by Mycobacterium tuberculosis, 2014, Cell Death and Disease, Vol 5 (7) DOI: 10.1038\/cddis.2014.313<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Solans L., Aguil\u00f3 N., Samper S., Pawlik A., Frigui W., Mart\u00edn C., Brosch R., Gonzalo-Asensio J. A.,\u00a0 Specific polymorphism in Mycobacterium tuberculosis H37Rv causes differential ESAT-6 expression and identifies whiB6 as a novel ESX-1 component, 2014, Infection and Immunity, Vol 82 (8)<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Solans L., Gonzalo-Asensio J., Sala C., Benjak A., Uplekar S., Rougemont J., Guilhot C., Malaga W., Mart\u00edn C., Cole S.T., The PhoP-Dependent ncRNA Mcr7 Modulates the TAT Secretion System in Mycobacterium tuberculosis, 2014, PLoS Pathogens, Vol 10 (5) DOI: 10.1371\/journal.ppat.1004183<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Aguilo N., Toledo A.M., Lopez-Roman E.M., Perez-Herran E., Gormley E., Rullas-Trincado J., Angulo-Barturen I., Martin C., Pulmonary Mycobacterium bovis BCG vaccination confers dose-dependent superior protection compared to that of subcutaneous vaccination,2014, Clinical and Vaccine Immunology, 21 (4) DOI: 10.1128\/CVI.00700-13<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Aguil\u00f3 N., Marinova D., Mart\u00edn C., Pardo J., ESX-1-induced apoptosis during mycobacterial infection: To be or not to be, that is the question, 2013 Frontiers in Cellular and Infection Microbiology, Vol 3 (DEC), DOI 10.3389\/fcimb.2013.00088<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Marinova D., Gonzalo-Asensio J., Aguilo N., Martin C., Recent developments in tuberculosis vaccines, 2013, Expert Review of Vaccines, Vol. 12 (12), DOI: 10.1586\/14760584.2013.856765<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Aguilo J.I., Alonso H., Uranga S., Marinova D., Arbu\u00e9s A., de Martino A., Anel A., Monzon M., Badiola J., Pardo J., Brosch R., Martin C., ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis, 2013, Cellular Microbiology, Vol\u00a0 15 (12), DOI 10.1111\/cmi.12169<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Arbues A., Aguilo J.I., Gonzalo-Asensio J., Marinova D., Uranga S., Puentes E., Fernandez C., Parra A., Cardona P.J., Vilaplana C., Ausina V., Williams A., Clark S., Malaga W., Guilhot C., Gicquel B., Martin C., Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials, 2013, Vaccine, Vol. 31 (42), DOI:10.1016\/j.vaccine.2013.07.051<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Aporta A., Arbues A., Aguilo J.I., Monzon M., Badiola J.J., de Martino A., Ferrer N., Marinova D., Anel A., Martin C., Pardo J., Attenuated Mycobacterium tuberculosis SO2 Vaccine Candidate Is Unable to Induce Cell Death, 2012, PLoS ONE, Vol. 7(9), DOI: 10.1371\/journal.pone.0045213<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Nambiar J.K., Pinto R., Aguilo J.I., Takatsu K., Martin C., Britton W.J., Triccas J.A., Protective immunity afforded by attenuated, PhoP-deficient Mycobacterium tuberculosis is associated with sustained generation of CD4 + T-cell memory,2012, European Journal of Immunology, Vol. 42(2), DOI:10.1002\/eji.201141903<\/span><\/p>\n<p>[\/vc_column_text][vc_empty_space]<h2 style=\"text-align:left;font-size:24px;line-height:28px;\" class=\"tm-custom-heading \" ><\/h2>\n[vc_column_text][\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;1\/4&#8243; css=&#8221;.vc_custom_1610458272385{margin-top: -24px !important;}&#8221;][vc_column_text] VACCINES [\/vc_column_text][vc_wp_custommenu nav_menu=&#8221;38&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text]Moreo, E., Uranga, S., Pic\u00f3, A., G\u00f3mez, A.B., Nardelli-Haefliger, D., Del Fresno, C., Murillo, I., Puentes, E., Rodr\u00edguez, E., Vales-G\u00f3mez, M., Pardo, J., Sancho, D., Mart\u00edn, C., Aguilo, N., Novel intravesical bacterial immunotherapy induces rejection of BCG-unresponsive established bladder tumors, 2022, Journal for ImmunoTherapy of Cancer, vol &hellip; <a href=\"https:\/\/genmico.unizar.es\/en\/evolution-and-vaccines\/publicaciones\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Publications<\/span><\/a><\/p>\n","protected":false},"author":31,"featured_media":0,"parent":2891,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/genmico.unizar.es\/en\/wp-json\/wp\/v2\/pages\/3083"}],"collection":[{"href":"https:\/\/genmico.unizar.es\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/genmico.unizar.es\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/genmico.unizar.es\/en\/wp-json\/wp\/v2\/users\/31"}],"replies":[{"embeddable":true,"href":"https:\/\/genmico.unizar.es\/en\/wp-json\/wp\/v2\/comments?post=3083"}],"version-history":[{"count":7,"href":"https:\/\/genmico.unizar.es\/en\/wp-json\/wp\/v2\/pages\/3083\/revisions"}],"predecessor-version":[{"id":3149,"href":"https:\/\/genmico.unizar.es\/en\/wp-json\/wp\/v2\/pages\/3083\/revisions\/3149"}],"up":[{"embeddable":true,"href":"https:\/\/genmico.unizar.es\/en\/wp-json\/wp\/v2\/pages\/2891"}],"wp:attachment":[{"href":"https:\/\/genmico.unizar.es\/en\/wp-json\/wp\/v2\/media?parent=3083"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}