Our Research Group of Mycobacterial Genetics has been working since 1992 in four lines of research financed by European and national investigation funds and that has permitted it to acquire an internationally recognized prestige. These lines of research include:

1 - Construction of New Vaccines against Tuberculosis

2 - Molecular Epidemiology of Tuberculosis

3 - Molecular Bases of the Resistance of mycobacteria

4 - Transposition and Latency of M. tuberculosis

The objectives of our group are to study the complexity of M. tuberculosis in a multidisciplinary focus and our group is coordinated with other national and international groups. More concretely we focus our research in:

 

1 - Genes implicated in the pathogenicity and virulence of M. tuberculosis

2 - Molecular epidemiology of tuberculosis, risk factors of transmission, and differences between strains of major epidemiological importance

3 - Mechanisms of resistance

4 - The mechanism of slow growth of the Koch bacillus


Active Projects

  • TBVAC2020 Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development.
    Chief Researcher and Coordinator: Carlos Martín Montañes

  • MM4TB More Medicines for Tuberculosis.
    European Union Organization
    Chief Researcher and Coordinator: José Antonio Ainsa

  • NAREB Nanotherapeutics for antibiotic resistant emerging bacterial pathogens
    European Union Organization
    Chief Researcher and Coordinator: José Antonio Ainsa

  • BIO2014-52580-P: Innovating MTBVAC as a vaccine against tuberculosis and new therapeutic applications for cancer.”
    MCyT/DGI/FEDER Organization
    2015-2017
    Chief Researcher and Coordinator: Carlos Martín

  • INNPACTO: Ref. IPT-2012-0327-090000. Vacuna Inactivada contra la tuberculosis en base a una cepa modificada genéticamente
    Ministerio de Economía y Competitividad Organization– Universidad de Zaragoza, Universidad Complutense and Biofabri. Feder Founds.
    Chief Researcher and Coordination : Carlos Martín

  • Polimorfismos genómicos y transcriptómicos en M. tuberculosis complex y su significado en clínica. 
    FIS, Instituto de Salud Carlos III Organization
    Chief Researcher and Coordination : Sofía Samper

  • Study of the impact of RD8 on the regulation of ESAT-6 secretion in Mycobacterium bovis and Mycobacterium africanum. SecRegulTBC.
    REFBIO Organization
    Chief Researcher and Coordination: Sofía Samper

  • Título del proyecto: antimicrobial resistance, virulence and new therapies in bacterial human pathogens. 
    REFBIO Organization
    Chief Researcher and Coordination : Sofía Samper

  • GRANT/2013/003 European reference laboratory network for tuberculosis (ERLTB-Net) - to strengthen TB diagnosis, drug susceptibility testing and coordination at European Union level. 
    ECDC Organization
    Chief Researcher and Coordination: Sofía Samper

  • Collaboration Agreement between the Government of Aragon and the University of Zaragoza.
    Molecular studies of tuberculosis..

  • Collaboration Agreement between Glaxo Smithkline Investigation and Development SL and the University of Zaragoza. Analysis and evaluation of antituberculous compounds.

  • OTRI Genetic Studies of Mycobacterium tuberculosis strains derived from an “x” area of the Community of Madrid, Autonomous Community of Galicia, General Hospital of Castellón and other Autonomous Communities.